Paving the way globally in microbial efficacy, we have a highly comprehensive portfolio
of efficacy testing in ultrasound probe high level disinfection.

We go further…


Nanosonics conducts extensive laboratory testing, focused on continually validating the effectiveness of trophon. Patient safety and reducing the risk of infection spread is paramount to us and drives our clinical research and testing.

Going far beyond the minimum regulatory requirements, we prioritise having the broadest possible microbial efficacy program. This absolute dedication to going further really sets us apart and ensures we exceed standards in HLD.

trophon is a pioneer globally in microbial efficacy, the first HLD system in the world proven to kill native, infectious, high-risk HPV.1

    • trophon inactivates the mandated subset of microorganisms, as required by Australian regulations.
    • trophon is proven to also eliminate an extended range of clinically infectious pathogens that other HLD products do not, including:*

– Sexually Transmitted Infections (STIs)

Clostridium difficile spores

– Drug resistant bacteria

1. Ryndock E, Robison R, Meyers C. Susceptibility of HPV16 and 18 to high level disinfectants indicated for semi-critical ultrasound probes. J Med Virol. 2016;88(6):1076-80.

Sexually Transmitted Infections (STIs)

Ultrasound probes frequently contact body sites where STIs can occur. trophon is proven to completely inactivate a range of STI causing pathogens.*


HIV


Human immunodeficiency virus (HIV) is an incurable disease that effects the immune system, impairing its ability to fight disease.






HIV


Around 25,313 people were living with HIV in Australia at the end of 2015, of which 10% were unaware of their HIV-positive status.1
trophon has been shown to inactivate HIV in laboratory tests.

Hepatitis B


Hepatitis B (HBV) infection attacks the liver and can be transmitted through body fluids (e.g. during sexual contact).






Hepatitis B


In 2015, an estimated 232,600 people had chronic Hepatitis B infection in Australia, of whom only 62% were diagnosed.1
trophon is effective against Hepatitis B on ultrasound probes.

Hepatitis C


Hepatitis C virus (HCV) is a blood borne virus that can cause chronic infection and liver diseases like liver cancer.






Hepatitis C


An estimated 227,306 people are living with chronic Hepatitis C infection in Australia with approximately 10,790 new cases diagnosed in 2015.1
trophon is effective against Hepatitis C on ultrasound probes.

HPV


HPV 16/18 infection which is the main cause for cervical cancers is present in an estimated 8.5% of Australian women.2




HPV

trophon is effective against HPV on ultrasound probes.

Chlamydia


Chlamydia trachomatis is the second most common notifiable disease in Australia and can result in infertility and ectopic pregnancy. 1



Chlamydia trachomatis

At the end of 2015, a total of 66,033 new Chlamydia cases were identified in Australia, a majority of which (77%) occurred in young people aged
15-29 years old.1
trophon is effective against Chlamydia on ultrasound probes.

Gonorrhea


Neisseria gonorrhoeae is a sexually transmitted disease that infects both women and men and, if left untreated, can lead to infertility.




Gonorrhea

In 2015, about 18,588 new cases of gonorrhoea were notified in Australia. A trend towards increase in gonorrhoea rates has been observed in both males and females since 2006 through to 2015.1
trophon is effective against Gonorrhea on ultrasound probes.

 

Candida


Candida albicans can cause fungal infection in the throat and vagina as well as bloodstream infections resulting in high rates of morbidity and mortality.




Candida

Yearly incidence of candidemia in Australia was 1.81 cases per 100,000 population according to a population based surveillance study between 2001 and 2004.3
trophon is effective against Candida on ultrasound probes.

 
1. The Kirby Institute. HIV, viral hepatitis and sexually transmissible infections in Australia Annual Surveillance Report 2016. The Kirby Institute, UNSW Australia. 2016. Available from: http://kirby.unsw.edu.au/sites/default/files/hiv/resources/SERP_2016-Annual-Surveillance-Report_UPD170116.pdf. Accessed 19 April 2017.
2. ICO Information Centre on HPV and Cancer. Australia, Human Papillomavirus and Reklated Cancers, Fact Sheet. 2016. Available from: http://www.hpvcentre.net/statistics/reports/AUS_FS.pdf. Accessed 19 April 2017.
3. Yapar N. Epidemiology and risk factors for invasive candidiasis. Ther Clin Risk Manag. 2014; 10: 95–105.
* Nanosonics internal test data.

Clostridium difficile spores

High level disinfectants are only required to be sporicidal at extended contact times. trophon has been shown to inactivate Clostridium difficile spores even within its manufacturer specified seven-minute cycle time in laboratory testing.*


 

Clostridium difficile


Clostridium difficile is a common hospital acquired infection (HAI), characterised by severe diarrhoea. The incidence of Clostridium difficile infection (CDI) is increasing.





Clostridium difficile

According to prospective national surveillance of public hospital-diagnosed CDI in Australia (hospital identified CDI increased significantly from 3.25 for every 10,000 patient days in 2011 to 4.03 for every 10,000 patient days in 2012).1,2

trophon is effective against Clostridium difficile spores.

 
1. Difficile Infection (CDI). Updated on 9 Feb 2016. Available from: http://www.health.gov.au/internet/main/publishing.nsf/Content/cda-phlncd-clostridium-difficile-infection-(CDI).htm. Accessed 19 April 2017.
2. Tracey L, Lirke A, Armstrong P and Riley TV. From the hospital to the home – the rise and rise of Clostridium difficile infection. Australian Family Physician – Abdomen. 2015; 44(10):712-717. http://www.racgp.org.au/afp/2015/october/from-the-hospital-to-the-home-%E2%80%93-the-rise-and-rise-of-clostridium-difficile-infection/
* Nanosonics internal test data.

Drug resistant bacteria

Drug resistant bacteria outbreaks in healthcare facilities are a real threat and antibiotics are ineffective against these strains. trophon inactivates these drug resistant bacteria.*


MRSA


Methicillin-resistant Staphylococcus aureus is antibiotic resistant and a common cause of many HAIs.




MRSA

Infection with MRSA can cause skin infections and can lead to more severe diseases including sepsis, pneumonia and bloodstream infections.
trophon is effective against MRSA on ultrasound probes.

VRE


Vancomycin-resistant Enterococci (VRE) have resistance to one of the last resort antibiotics available.1




VRE

Enterococci reside in the gut and symptoms can be severe. Infection can occur from contaminated healthcare settings.
trophon is effective against VRE on ultrasound probes.

CRE


Infection with Carbapenem-resistant enterobacteriaceae (CRE) can cause severe morbidity and death.





CRE

Enterobacteriaceae resistance to cephalosporins is on a rise in Australia and in 2015, an increase in detection and spread of type of CRE called Klebsiella pneumoniae carbapenemase-producing bacteria (KPC) was reported in some Australian hospitals. 2,3
trophon is effective against CRE on ultrasound probes.

1. Reed D, Kemmerly SA. Infection Control and Prevention: A Review of Hospital-Acquired Infections and the Economic Implications. The Ochsner Journal. 2009;9(1):27-31.
2. Facing the challenge of multi drug resistant gram-negative bacilli in Australia. Medical Journal of Australia – clinical Focus. 2015; 202(5): 243-247. Available from: https://www.mja.com.au/system/files/issues/202_05/har01257.pdf
3. Healthcare Associated Infections Program. Prevention And Management Of Carbapenem resistant Enterbacteriaceae In NSW Hospitals – Information For Clinicians. Clinical Excellence Commission 2015. Available from: http://www.cec.health.nsw.gov.au/__data/assets/pdf_file/0009/258642/CRE-Fact-Sheet-2015-21-Sep-2015.pdf. Accessed on 19 April 2017.
* Nanosonics internal test data.

TGA Mandatory Testing Requirements

The TGA has minimum requirements for HLD. trophon inactivates all of the mandated microorganisms.*


Mycobactericidal


Mycobacteria can cause serious diseases like tuberculosis. HLD should eliminate mycobacteria within contact time.




Mycobactericidal

Mycobacteria have a tough cell wall and are highly resistant to disinfectants.
trophon is effective against Mycobacteria on ultrasound probes.

Fungicidal


Fungi and yeast are opportunistic pathogens. High level disinfection should be effective against fungi.




Fungicidal

Fungi and yeast can be highly resistant to disinfection. They can take advantage of a change in a patient’s health (e.g. immunocompromised status).
trophon is effective against fungi and yeast on ultrasound probes.

Bactericidal


Vegetative bacteria (such as E. Coli) cause a wide variety of infectious diseases in healthcare and in the community.




Bactericidal

All TGA registered disinfectants should demonstrate activity towards vegetative bacteria.
trophon is effective against vegetative bacteria on ultrasound probes.

Sporicidal


Bacterial spores are extremely resistant to disinfectants. High level disinfectants are only required to be sporicidal at extended contact times.


Sporicidal

Spores like Clostridium difficile can cause severe diarrhoea and is a leading contributor to the HAI disease burden in our healthcare systems.


trophon is effective against sporicidal on ultrasound probes.

 

Virucidal


Viruses (unlike bacteria) require a host for replication. HLD should inactivate enveloped and non-enveloped viruses.


Virucidal

Viruses can survive in the environment or on surfaces for periods of time. They can be transmitted via air, droplets, body fluids and contact with surfaces.
trophon is effective against viruses on ultrasound probes.


 Full range of organisms tested against
Vegetative bacteria Fungi
Carbapenam resistant Escherichia coli Candida albicans
Staphylococcus aureus Aspergillus niger
Pseudomonas aeruginosa Viruses
Enterococcus hirae Polio virus
Methicillin-resistant Staphylococcus aureus Adenovirus
Vancomycin-resistant Enterococcus Human hepatitis B virus surrogate (duck hepatitis B virus)
Neisseria gonorrhoea Human immunodeficiency virus type 1
Mycobacteria Hepatitis C virus surrogate (Bovine viral diarrhoea virus)
Mycobacterium terrae Human papillomavirus (HPV16 and HPV18)
Bacterial endospores Chlamydia
Geobacillus stearothermophilus Chlamydia trachomatis (ATCC strain)
Bacillus subtilis
Bacillus cereus
Clostridium difficile

 


Proven effective against a wide range of microorganisms,
you can have confidence in trophon.